New Research in Antibiotic-Resistant Bacteria (Page 1/1)
Notorio JUN 11, 11:31 PM
I've come home from the hospital with antibiotic-resistant bacteria in the past and know other people who have suffered from that, having much more difficult recoveries. This research is taking a different approach to the problem and seems quite interesting ... unfortunately you can't read the original article in Science magazine without a subscription.

Researchers Discover Critical Role of Hydrogen Sulfide in Ability of Bacteria to Survive Antibiotics
rinselberg JUN 11, 11:43 PM
I scrolled through that, reading some, but not very attentively. It seems promising.

When I came to the end, I saw a reference to the Blavatnik Family Foundation. I thought that might be something to do with the legacy or descendants of one Madame (H.P.) Blavatsky. Because I couldn't remember exactly that name.

It's well, I think, that the Blavatnik Family Foundation is not what I thought it might be: The Blavatsky Foundation.

It's well, or at least, not "ill" in any way.

I don't think I am missing anything by not having access to the actual research paper or the original article, as you called it.
sourmash JUN 12, 08:42 AM
Wat?!

Regarding drug resistance and medications, there's a huge problem with 3rd world countries misusing medications. They use and try to mimic our medical system but don't really grasp the nuances of it.

1st world ideology related: another problem is exhibited in the cold and flu season that became known as Covid 19. People fear-steered to take experimental injections. It shows how people will disregard safety and prudence to push massive overuse of a drug before it's ready for that mass usage.

But those are problems and the article is probably about answers.
Notorio JUN 12, 11:54 AM

quote
Originally posted by rinselberg:

...

I don't think I am missing anything by not having access to the actual research paper or the original article, as you called it.




I'm slowly talking myself into getting the annual subscription. In this case I'd be interested to learn about the 'virtual screening method' they used to consider 3 Million chemicals and narrow down to just 3 to put into lab trials.
maryjane JUN 12, 12:33 PM
An interesting article.
another with a little more text:
https://www.fiercebiotech.c...tible-to-antibiotics
maryjane JUN 12, 12:54 PM

quote
Originally posted by Notorio:


I'm slowly talking myself into getting the annual subscription. In this case I'd be interested to learn about the 'virtual screening method' they used to consider 3 Million chemicals and narrow down to just 3 to put into lab trials.


Perhaps because the 3 lead compounds mentioned have shown previous promising results in other medical research. Lead compound NL1 is a Thiazolidinedione.

randye JUN 12, 05:55 PM
Hmmmm

There are over 200 species of chemolithotropic bacteria that produce hydrogen sulfide as a waste product from feeding on organic matter.

Oxygen is generally lethal to these microorganisms and their H2S waste product combines with O2 to produce weak sulfuric acid that "protects" the bacterial colony.

By the way, hydrogen sulfide is that gas with the strong "rotten eggs" smell from bacterial decay of oxidized sulfur naturally contained in organic and inorganic compounds.


(Years ago I did a lot of work on biocidal materials for medical devices for a client. Some of the foundational info stuck with me.....)

[This message has been edited by randye (edited 06-12-2021).]